Last year's Carling Cup victors Manchester United defend their crown at Wembley on Sunday when they take on five-time winners Aston Villa.
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Chelsea face Manchester City in Saturday's game of the day while Birmingham City entertain Wigan and Bolton play Wolves in a relegation six-pointer.
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France continue their quest for a Grand Slam when they take on Wales in Cardiff on Friday while Italy play Scotland in Rome and England face Ireland.
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Liverpool, Everton and Fulham will all be hoping to reach the last 16 in the Europa League when they take to the field on Thursday evening.
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Champions League action gets back underway for Chelsea on Wednesday as they face a tough trip to Italy to face Internazionale in the last 16.
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Manchester United must get their title challenge back on track against West Ham United on Tuesday following Saturday's shock 3-1 defeat to Everton.
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Rotherham United play host to Shrewsbury Town on Monday evening with both sides looking to escape for the bottom rung of the Football League ladder.
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Manchester City play host to Liverpool as the race for a top-four finish intensifies while Spurs entertain Wigan Athletic and Aston Villa face Burnley.
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Wayne Rooney returns to former club Everton with Manchester United this weekend while league leaders Chelsea travel to Wolves and Arsenal face Sunderland.
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Warrington's derby clash with Wigan is the highlight of this weekend's Super League fixtures while Leeds take on Salford and Crusaders host Hull.
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Liverpool face Unirea Urziceni in the Europa League while Fulham have a tough two-legged affair against holders Shakhtar Donetsk to look forward to.
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The Champions League returns on Tuesday evening, with David Beckham taking centre stage as Manchester United visit the San Siro to face AC Milan.
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Tiger Woods may be missing, but the Accenture Match Play Championship once again looks set to be one of the highlights of the golfing year.
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FA Cup holders Chelsea face a potential banana skin in this season's fifth round with Championship high-flyers Cardiff City making the trip on Saturday.
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With this season's Six Nations competition well and truly underway, there are another three action-packed contests to look forward to this weekend.
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Traditional powers Leeds Rhinos and St Helens will be looking to get back on track after suffering defeats in the Super League last weekend.
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Liverpool's trip to Arsenal tops the Premier League bill on Wednesday evening, with leaders Chelsea facing a tough trip to Goodison Park to face Everton.
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Manchester City will hope to get their top-four challenge back on track when they face Bolton Wanderers in a local derby on Tuesday evening.
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Colchester United and Southend United meet in a League One Essex derby on Monday evening at Weston Homes Community Stadium, but who will come out on top?
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Everton will be desperate to gain revenge for their Goodison defeat against Liverpool in November when Anfield hosts the second derby clash of the season.
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Grand Slam champions Ireland face a tough task if they are to retain their Six Nations crown this season, with Wales, England and France all contenders.
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Paul Casey, Lee Westwood and Rory McIlroy are among the favourites for this week's Dubai Desert Classic, the first big tournament of the year.
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Beleaguered Portsmouth return to Premier League action on Wednesday night with a trip to Fulham looking to claw their way off the foot of the table.
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Sunderland's poor run of form in recent weeks means that Stoke City will head to the Stadium of Light full of confidence for Monday evening's showdown.
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