English and German rivalries will be on show on Tuesday evening with Bayern Munich welcoming old foes Manchester United to the Allianz Arena.
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Wigan Athletic's leaky defence will be put to the test on Monday when the Latics visit a Manchester City side that remains in contention for the top four.
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Title-chasing Chelsea and Aston Villa meet at Stamford Bridge in the pick of this Saturday's Premier League fixtures as the race for the title hots up.
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After a dull opening to the new year in Bahrain a fortnight ago, Formula One needs an entertaining Australian Grand Prix to kick-start the season.
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The run-up to the Masters at Augusta finishes with the Arnold Palmer Invitational at Bay Hill, where the field can relax in the absence of Tiger Woods.
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Manchester City's bid to finish fourth in the Premier League and qualify for the Champions League steps up when they take on Everton on Wednesday evening.
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Aston Villa face near-neighbours Wolves while Spurs take on Stoke City as the race for fourth spot in the Premier League reaches a critical point.
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England are strong favourites to win the second Test match against Bangladesh in Dhaka, having won by 181 runs in the first Test in Chittagong.
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Few sides can afford to take it easy when the second legs of the round of 16 ties in the Europa League take place across Europe on Thursday evening.
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Holders Barcelona and Bordeaux are expected to complete the line-up for the Champions League quarter-finals when they go into action on Wednesday evening.
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Liverpool must win at home to rock-bottom Portsmouth on Monday evening to have any chance of finishing in fourth place in the Premier League.
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Manchester United continue their quest for a fourth successive title when they entertain Fulham while Manchester City visit Sunderland on Sunday.
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Chelsea face West Ham in Saturday's game of the day while towards the foot of the table Bolton Wanderers face Wigan Athletic and Burnley entertain Wolves.
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England will be confident of success going into the first Test against Bangladesh, despite the absence of Andrew Strauss and a number injury problems.
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Liverpool and Fulham are flying the flag in this season's Europa League and they both face away-day trips to Lille and Juventus respectively on Thursday.
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All eyes will be on the FA Cup quarter-finals this weekend and there are likely to be some fireworks on show with a trip to Wembley just one win away.
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The eight teams that remain in this season's FA Cup can put their league aspirations to one side and dream of a trip to the Home of Football.
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Arsenal are big favourites to enhance their title credentials by beating Burnley this weekend while Manchester United should overcome Wolves at Molineux.
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After their disappointment at losing a second consecutive World Club Challenge, Leeds will be looking to pick up two points at home to Harlequins.
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All the talk over Ashley Cole, Wayne Bridge and John Terry has overshadowed the fact that England have an important friendly against Egypt on Wednesday.
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The new F1 season is just two weeks away but it is fair to suggest there are certainly more questions than answers surrounding the 2010 campaign.
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