England face a make-or-break showdown with Australia, with a place in the final of the Four Nations tournament on the line for Steve McNamara's side.
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It's the World Series match-up few predicted at the start of the play-offs with the Texas Rangers and San Francisco Giants set to go head-to-head.
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Newcastle United play host to Arsenal in the pick of Wednesday night's Carling Cup ties, looking to repeat their success against Chelsea in the last round.
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The Carling Cup has reached the last 16 stage and Tuesday night sees the first five ties played, with favourites and holders Manchester United in action.
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Cardiff City will be looking to continue their push to secure promotion from the Championship by beating mid-table Leeds United at Elland Road.
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If they can beat Arsenal on Sunday then any lingering doubts about Manchester City's ability to mount a serious title challenge will surely be over.
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Reigning Premier League champions Chelsea take on Wolves on Saturday afternoon knowing a victory will send them five points clear at the top of the table.
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Liverpool aim to put all their problems behind them when they take on Napoli in the Europa League while Manchester City face Polish side Lech Poznan.
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Chelsea and Arsenal's 100 per cent starts to the Champions League group stage come under threat this week by Spartak Moscow and Shakhtar Donetsk.
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Blackburn Rovers and Sunderland meet at Ewood Park on Monday, with both sides keen to take three points and move into the top half of the table.
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Goodison Park hosts the first Merseyside derby of the campaign while Manchester City look to extend their winning sequence to four by beating Blackpool.
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League leaders Chelsea go to Aston Villa on Saturday as they look to strengthen their grip over Manchester City, United and Arsenal at top of the table.
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The second round of Heineken Cup matches takes centre stage in the world of rugby union this weekend, with a number of tough encounters on the cards.
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England will hope to make it three wins out of three when they take on Montenegro in a European Championship qualifier on Tuesday evening.
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A toothless Scotland side have the unenviable job of trying to beat reigning World Cup and European Championship holders Spain at Hampden Park.
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Swindon, beaten play-off finalists in May, need three points in their local derby with Bristol Rovers to get their season moving in the right direction.
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A MotoGP season which has been badly affected by injuries to key figures moves on to Sepang this weekend, with Jorge Lorenzo set to be crowned champion.
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The Heineken Cup gets underway this weekend, with French outfit Toulouse the defending champions and expected to go close again this term.
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McLaren's Lewis Hamilton must complete this weekend's Japanese Grand Prix if he is to remain in touching distance with his Formula One championship rivals.
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With a place in the Football League at stake, big-spending Crawley Town are making the early running at the top of the Conference National table.
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Sheffield Wednesday and Charlton Athletic are two former Premier League sides that want to reach Wembley in the Johnstone's Paint Trophy this season.
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Manchester United will hope to kick-start a stuttering Premier League campaign when they travel to the Stadium of Light to take on Sunderland.
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Wigan Warriors will be attempting to win their first Grand Final since 1998 when they tackle fierce local rivals St Helens at Old Trafford on Saturday.
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