There are two Premier League fixtures this week with Hull City facing a depleted Everton side and Fulham taking on a buoyant Blackburn Rovers on Wednesday evening.
Hull, who are overwhelming sportsbook favourites to suffer relegation this term, will be out to gain revenge for the 4-0 thumping Everton dished up in the Carling Cup earlier this season.
A win may not come easy and you would have to go back to December 1952 for the last Tigers victory against the Blues.
The Merseysiders, with a string of first-team players remaining on the sidelines through injury, continue to struggle as they try and find a winning formula
However, boss David Moyes will be confident of leaving Humberside with three much needed points as his side look to change their recent fortunes around, with just one win from their last six games.
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He is still without the services of James Vaughan, Victor Anichebe, Steven Pienaar, captain Phil Neville, Phil Jagielka and Mikel Arteta, who all have knee injuries.
Diminutive midfielder Leon Osman is also expected to miss out with a groin complaint, while Marouane Fellaini and Diniyar Bilyaletdinov sit out through suspension.
Fulham face a Blackburn Rovers side who will still be ecstatic following their away day success at Bolton Wanderers on Sunday afternoon.
The win halted their abysmal run on the road this term and the victory will have pleased their temporarily departed boss Sam Allardyce, who is undergoing minor heart surgery this week.
Assistant manager Neil McDonald took charge at Reebok Stadium and he will be holding the fort once again as they look to continue their rise up the table.
The recent head-to-heads also favour the visitors.
In the last six clashes the Lancashire outfit have won three and drawn three and Fulham, with just one clean sheet in their last 11 games, need to steady their leaky defence if they are to arrest this run.
Despite last weekend's win, Rovers would be foolish to think they have turned the corner. Prior to the Bolton win they had lost ten consecutive games on their travels.
Fulham boss Roy Hodgson will be hoping his trio of forwards can win their fitness battles.
Erik Nevland (virus), Diomansy Kamara (ankle) and Andrew Johnson (groin) are all set to miss the clash, while former Liverpool and Tottenham Hotspur midfielder Danny Murphy will not recover in time from a knee injury.