Manchester rivals City and United go head-to-head on Saturday afternoon in a clash that promises to be one of the most keenly contested derbies in recent memory, with City closing in on their target of fourth place and United desperate to stay in the title race behind favourites Chelsea.
A win for either side will heavily disrupt their local rival's hopes so the tension and pressure is sure to be at fever pitch.
One man who has been there and done it all before is United's Ryan Giggs who incredibly has appeared in all 28 Mancunian league derbies played since making his debut in one in May 1991.
Despite his advancing years, he still loves playing against City, having scored one and assisted four times against them already this season.
Recent clashes between the sides suggest a high-scoring game, with 14 goals being scored in the three meetings so far this term.
A last-gasp Michael Owen strike secured a 4-3 Premier League win at Old Trafford for the Red Devils in September while it was the red side of the city that won the bragging rights again as they overturned a League Cup semi-final 2-1 first leg deficit around by grabbing a 3-1 and 4-3 aggregate triumph on home soil to earn a place at Wembley.
Tottenham's tough run-in continues as they host Premier League leaders Chelsea in Saturday's evening kick-off.
Spurs' midweek victory against bitter rivals Arsenal, their first win against the Gunners since 1999, will only serve to galvanize them in their quest for fourth spot.
Carlo Ancelotti's men battled to a 1-0 win over Bolton on Tuesday, taking them four points clear of title rivals Manchester United.
Clearly both sides have a lot to play for and a hotly contested London derby, Spurs' second in a week, is surely to be expected.
Chelsea have won their last four games scoring 15 goals in the process. Their recent record at White Hart Lane, however, is less impressive with the Blues having not tasted victory away at Tottenham in their last three attempts, losing twice.
Burnley will look to press on from their shock 4-1 victory against fellow relegation threatened side Hull City last weekend and secure back to back Premier League wins for only the second time and the first time since August.
After winning just one point from their opening 16 games on the road this season, the Clarets' win over Hull was the first time that they have secured all three points available on the road this season.
Their home form has been better, with one of their vital victories at Turf Moor this term coming against Sunderland in their earlier meeting this season as they secured a 3-1 win but it is the Black Cats who are the overwhelming sportsbook favourites to gain revenge this weekend.
Elsewhere, Everton will be looking to aid their European qualification challenge with a win at Blackburn Rovers and mid-table Birmingham City meet Hull City at St Andrew's.
Europa League heroes Fulham take on Wolverhampton Wanderers at Craven Cottage while Stoke City and Bolton Wanderers go head-to-head at Britannia Stadium.