Rafa Benitez takes his Liverpool squad to face Champions League minnows Debrecen in Hungary on Tuesday evening knowing that only a victory will give his side any chance of progressing to the knock-out stage of this year's competition.
A failure in Budapest may result in the Spaniard's dismissal as the pressure intensifies on the Anfield club.
With Steven Gerrard and Fernando Torres still not fully-fit, much rests on Liverpool's other players to pull them out of the fire.
Lyon, who have already qualified for the last 16, visit Fiorentina in Florence and a Viola success will see the Reds crash out.
Arsenal will be looking to confirm their promise with a home test against Belgian outfit Standard Liege.
The Gunners, who are on the verge of qualifying from Group H, are in emphatic form in Europe and will want another resounding success.
Arsene Wenger may opt to select some of his younger players in order for them to gather some valuable European experience.
Carlos Vela, Fran Merida and Aaron Ramsey could be set to feature as their burgeoning careers continue to gather pace.
Olympiacos travel to rock-bottom Dutch side AZ Alkmaar and a win for the Greeks would surely guarantee their place in the next stage of the competition.
Rubin Kazan face Dinamo Kiev and a win for either side will worry their Group F powerhouse rivals Barcelona and Internazionale, who clash at the Nou Camp in the undoubted showdown of the night.
Barcelona remain one of the online sportsbook favourites to retain the trophy at the end of the season despite their uncomfortable position.
Only two points separate Jose Mourinho's Inter at the top of the table and Kiev at the foot with just two intriguing match-days remaining.
In Group G, Rangers have it all to do if they are to clamber off the foot of the table. They face a struggling Stuttgart side at Ibrox and only a win will give Walter Smith's side any hope of gaining an unlikely place in the next round.
After four games they have picked up just two points while runaway group leaders Sevilla travel to Romania to face Unirea Urziceni.
Dan Petrescu's side are sitting pretty in second place and a win for them would put them firmly in the driving seat to follow Sevilla into the next stage of the competition.