Everton will be looking to kick-start their season by beating Manchester United on Saturday lunchtime after failing to win any of their first three Premier League matches of the campaign.
They will be boosted by last term's victory at Goodison Park against Sir Alex Ferguson's outfit as well as by United's less than impressive display in their last game away from Old Trafford - the 2-2 draw at Fulham.
Wayne Rooney will once again be in the spotlight on his return to his former club following the lurid allegations surrounding his private life which have emerged in recent days.
The former Everton fans' favourite is likely to be given a rough ride by a Goodison Park crowd that used to idolise him.
Elsewhere, after seeing off Sam Allardyce's current side Blackburn Rovers last time out, Arsenal come up against his former club, Bolton Wanderers, at the Emirates Stadium.
Owen Coyle has transformed Bolton into a good footballing side since replacing Gary Megson as boss midway through last term, which may be more to Arsene Wenger's liking.
Two unbeaten teams meet at Craven Cottage when Fulham, who have drawn all three of their matches so far, meet a Wolves team that has taken five points from their opening three games.
It is a particularly encouraging start by Mick McCarthy's team as they had been tipped for a season of struggle to avoid relegation by many pundits.
Sportsbook favourites Manchester City will be keen to get back on track against Blackburn after suffering a shock 1-0 defeat at Sunderland in their last game two weeks ago.
Sam Allardyce's team will also be looking for the right response after they were beaten 2-1 by Arsenal at Ewood Park last time out.
The London derby pits together two teams whose fortunes could not have been more contrasting in the opening month of the new campaign.
The arrival of Chelsea at Upton Park sees former players Frank Lampard and Yossi Benayoun return to West Ham United while ex-Blues star Scott Parker is now on the Hammers' pay-roll.
But while Chelsea once again appear certain to be challenging for honours this term, there is real concern that West Ham are going to become embroiled in a second successive battle to avoid relegation.
Harry Redknapp will have to re-jig his defensive line-up for Spurs' game against West Brom after Michael Dawson sprained his left medial knee ligament and a left ankle ligament during England's 4-0 win against Bulgaria last week.
Two teams that were playing in the Championship last season meet at St James' Park when Newcastle United entertain Blackpool while Steve Bruce comes up against one of his former clubs when he takes his Sunderland side to Wigan Athletic."