As the festive period nears, Premier League fixtures are beginning to pile up with just Fulham and Everton - who are in Europa League action - missing out on their domestic duties this week.
Manchester United face Wolverhampton Wanderers on Tuesday night at Old Trafford with both having varying success at the weekend.
The Red Devils lost to Aston Villa on Saturday in a result that shocked many as the reigning champions missed the opportunity to level up with table-toppers Chelsea after they managed a 3-3 draw with Everton at Stamford Bridge earlier in the day.
Wolves landed an excellent 1-0 against Tottenham Hotspur at White Hart Lane.
With Spurs flying-high at the top end of the table and Wolves at the bottom, the tables were certainly turned in the capital.
They may find the going that bit tougher against Sir Alex Ferguson's side and they will be a wounded beast after their home setback.
Manchester City travel to face Spurs on Wednesday and they will have been buoyed by their battling resilience in the 3-3 stalemate with Bolton Wanderers on Saturday.
Spurs will want to get back to winning ways following their disaster at the weekend but, with Mark Hughes' City maintaining their unbeaten run, it will be tough to call a winner.
Sunderland's fine home record will be tested against Aston Villa especially with England pair Ashley Young and Gabriel Agbonlahor combining to score in their 1-0 success at Old Trafford, who look in fine form this term.
Can Chelsea and Manchester United get back to winning ways in midweek? - Latest Football Betting
Birmingham City have a chance to extend their seven-game unbeaten run when they face Blackburn Rovers, who have been dismal on their travels this season.
Strugglers Bolton Wanderers and West Ham United will lock horns at the Reebok Stadium with both outfits in the relegation zone.
The remaining Wednesday fixtures will see Liverpool face Wigan Athletic and they must get back to winning ways at Anfield after yet another Premier League loss against Arsenal on Sunday.
Burnley have the unenviable task of tackling Arsene Wenger's youthful side at Turf Moor, although they should be quietly confident with a solid home record.
Leaders Chelsea, who remain the sportsbook favourites to win this season's Premier League title, like their nearest rivals Manchester United, will be thirsting to collect three points, this time over basement-boys Portsmouth.
Avram Grant returns to Stamford Bridge now that he is in charge of the south coast outfit and anything other than a home win would be a small miracle for his beleaguered troops.