Tottenham Hotspur and Fulham will lock horns in a London derby in the pick of Tuesday night's fixtures in the Premier League.
Harry Redknapp will be hoping his side can consolidate their top four push with a victory against Roy Hodgson's men at White Hart Lane.
Spurs will be disappointed they only managed to draw with League One side Leeds United in the FA Cup at the weekend but their shrewd coach will be pleased to be back in the thick of league action.
They lost their last league outing 2-0 against rivals Liverpool at Anfield on January 20 and with Manchester City and Aston Villa also chasing them, they need to get back to winning ways.
Spurs are overwhelming sportsbook favourites to claim the spoils against the Cottagers and they will be hoping to justify the faith placed in them.
Liverpool make a trip to the Midlands to face struggling Wolverhampton Wanderers at Molineux.
The Reds have endured a torrid season to date, although manager Rafael Benitez will be enthused that his side have picked up ten points from their previous four contests to shoot them into sixth position.
Mick McCarthy's side hover just one spot above the drop zone and any positive result against the Merseysiders must be seen as a huge success.
Wolves face showdowns against relegation threatened rivals Hull City and West Ham United following the clash against Liverpool.
All eyes will be on the Reebok Stadium with Bolton Wanderers and Burnley clashing in a Lancashire derby.
New Bolton boss Owen Coyle, who recently left Burnley, will be aiming to help his new side to victory against his former employers.
However, the Clarets will be using Coyle's move as their inspiration as they seek their first Premier League win on the road.
They have collected just one point from their 11 games away from Turf Moor and this a wretched sequence that needs to be arrested.
Basement boys Portsmouth welcome West Ham United to Fratton Park and a win for Avram Grant's men would significantly aid their plight.
The Hammers are in trouble themselves at the wrong end of the table but with David Gold and David Sullivan completing the club's takeover recently, Gianfranco Zola's men should be revitalised as they look to climb the table.