Liverpool stunned Manchester United in the Premier League on Saturday, upsetting the sportsbooks to come from behind and clinch a remarkable 4-1 victory at Old Trafford.
Cristiano Ronaldo opened the scoring from the penalty spot but Fernando Torres and Steven Gerrard gave Liverpool a 2-1 interval lead.
Nemanja Vidic was sent off before further goals by Fabio Aurelio and Andrea Dossena sealed a fine win for Rafa Benitez's side.
Arsenal moved up to fourth with a 4-0 win at home to Blackburn Rovers. Andrey Arshavin scored his first goal for the club while Emmanuel Eboue grabbed a brace and Andre Ooijer scored an own goal as the Gunners improved their chances of clinching a top-four place.
Everton remain in contention for a Champions League spot after beating Stoke City 3-1 at Goodison Park.
Brazilian striker Jo and Joleon Lescott gave David Moyes' side a two-goal lead and, although Ryan Shawcross pulled a goal back for Stoke, Marouane Fellaini grabbed a third for Everton in stoppage time.
Portsmouth led at Middlesbrough until stoppage time thanks to Peter Crouch's volley, but the points were shared when Marlon King netted with virtually the last kick of the match.
Geovanni's ninth-minute header put Hull City ahead against Newcastle United but the points were shared as Steven Taylor equalised before the break.
Sunderland are only three points clear of the drop-zone after losing 2-1 to Wigan Athletic at the Stadium of Light while Fulham moved up to ninth with a 3-1 victory at Bolton Wanderers.
In the Six Nations, Ireland stormed to within one win of only a second Grand Slam in their history - the other came in 1948 - after they came from behind to beat Scotland 22-15, while Wales rode their luck before securing a narrow 20-15 victory against Italy in Rome.
Meanwhile, Gloucester increased their lead at the top of the Guinness Premiership table with a crucial 24-22 victory against Wasps at Kingsholm.
In the day's other match, Ben Foden grabbed a try as Northampton Saints thrashed Sale Sharks 38-3 at Franklin's Gardens.
In rugby league, Warrington's miserable start to the new Super League season continued after they were thrashed 60-8 by a rampant Harlequins side while Huddersfield Giants got the better of Castleford Tigers with a dramatic 26-24 victory at The Jungle.
Finally in boxing, Amir Khan secured a fifth-round technical decision win over Mexican legend Marco Antonio Barrera.