Wales are 13/5 to keep their Euro 2016 dream alive by getting past Belgium to reach the semi-finals.
Belgium are now the 4/1 third favourites to win the tournament after bouncing back impressively from their opening defeat to Italy and Wales are the clear underdogs ahead of the match in Lille, with the Red Devils 18/25 to win in 90 minutes.
Marc Wilmots’ side have risen to the top of the world rankings in the past and sit at number two on the FIFA list but their failure to beat Wales in three games over the last two and a half years could cause extra nerves in the Belgium camp.
Paired together in the last two qualifying campaigns, Wales fought out 1-1 and 0-0 draws in Brussels before a memorable win in Cardiff a year ago and they are 5/1 for another victory without the need for extra time.
Gareth Bale believes those results could give Wales a psychological edge, saying: "We're like their bogey team, aren't we? Hopefully that edge gets into their heads - you never know. We will definitely draw on those qualifiers, it gives us more knowledge on them.
"We know how to play against them and how they play. We know it will be a different game from the qualifiers and it is a more pressurised situation. But we understand what they are about, how they work, and we will hone our game plan to try and stop them but help our attack."
The match within the match is the battle between Bale and Eden Hazard and the last time they shared the same international pitch a year ago the Real Madrid star came up with the winner in Wales' 1-0 victory.
Wales managed to shut Hazard out by crowding him whenever he had possession but the Chelsea forward is in fine form and Belgium will be praying he has fully recovered from a leg injury to play.
Bale is 23/2 to again score more goals than the opposition by himself and he is 21/5 to outscore Belgium striker Romelu Lukaku or 11/1 to score with a direct free-kick.
Hazard leads the assists chart after the last-16 stage, having set up three goals already, and he is 11/4 to produce another assist or 5/2 to add to the goal he scored against Hungary.
Wales will be desperate for captain Ashley Williams to overcome his shoulder injury, having been the rock at the heart of a well-organised defence for some years now. His absence would be a huge blow and Belgium are 7/2 to score at least three goals.