Super League leaders Warrington Wolves have been cut to 9/4 to win the Challenge Cup after being drawn against Cheshire neighbours Widnes in the quarter-finals.
The Wolves, who have done the double over the Vikings in Super League this season, will have home advantage in the tie, which will be played over the last weekend in June and Widnes are now the 33/1 outsiders.
Huddersfield were 20/1 ahead of the previous round but have now been slashed to 7/1, with their reward for knocking out holders Leeds being a home tie against Wakefield (25/1).
Hull (5/1) are at home to Catalans Dragons (6/1) and Castleford (20/1) visit 5/2 second-favourites Wigan. The tie at the DW Stadium is a repeat of the 2014 quarter-final in which Castleford beat Wigan on their way to Wembley, where they suffered a 23-10 loss to Leeds.
Hull coach Lee Radford is delighted with his side's pairing with Catalans Dragons and expects it to be a more open affair than the recent error-strewn league clash with the French club.
The Black and Whites triumphed 28-26 at the KC Stadium, completing the double following their 38-10 win over the Dragons in Perpignan back in February.
“It's a mouth-watering fixture,” Radford said. “We played them last week and it was a terrible game to watch but I think this will live up to expectations with so much at stake.”
The Catalans were runners-up in the first final to be played at the re-developed national stadium in 2007 while Hull's defeat by Wigan in 2013 preserved their unwanted record of never having won at Wembley.
Challenge Cup quarter-final draw:
Hull FC v Catalans Dragons
Wigan v Castleford
Warrington v Widnes
Huddersfield v Wakefield